Thyroid Disease: ABFM practice questions

19 board-style questions on thyroid disease in the PulseMD family medicine question bank — physician-reviewed, written against current guidelines with the reference cited on each question. Two free samples below; the full set with answers, explanations, and spaced review is free to start.

Sample question 1

A 38-year-old woman with Graves' disease is treated with methimazole 20 mg daily. Six weeks later, she presents with fever (39.2°C), sore throat, and malaise. Physical examination reveals pharyngeal erythema without exudate. A complete blood count shows WBC 1,200/μL with an absolute neutrophil count (ANC) of 200/μL. What is the most important immediate action?

  1. Stop methimazole, draw blood cultures, and start broad-spectrum antibiotics
  2. Continue methimazole and treat the sore throat with amoxicillin
  3. Decrease methimazole dose to 5 mg daily and repeat CBC in 1 week
  4. Switch to propylthiouracil and monitor CBC weekly thereafter

Sample question 2

A 45-year-old woman is found to have a 1.8 cm thyroid nodule on ultrasound performed for neck pain. The nodule is solid, hypoechoic, taller-than-wide, and has microcalcifications. TSH is 2.1 mIU/L (normal 0.5-4.5). What is the most appropriate next step?

  1. Fine-needle aspiration biopsy
  2. Radioactive iodine uptake scan
  3. Immediate thyroidectomy
  4. Repeat ultrasound in 12 months

Create a free PulseMD account to answer these, see the explanations, and practice five minutes a day.

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