SSRIs & Antidepressants: ABFM practice questions

21 board-style questions on ssris & antidepressants in the PulseMD family medicine question bank — physician-reviewed, written against current guidelines with the reference cited on each question. Two free samples below; the full set with answers, explanations, and spaced review is free to start.

Sample question 1

A 26-year-old woman presents with recurrent episodes of sudden-onset palpitations, chest tightness, shortness of breath, diaphoresis, trembling, and an overwhelming fear of dying. Episodes last 10-15 minutes, occur unpredictably 2-3 times per week, and have occasionally awakened her from sleep. She has visited the emergency department three times in the past month; each time cardiac workup including ECG, troponin, and echocardiography was normal. She has begun avoiding driving alone, grocery stores, and social gatherings for fear of having an episode in public. What is the most appropriate long-term treatment strategy?

  1. Propranolol 20 mg as needed before anticipated anxiety triggers
  2. Gabapentin 300 mg three times daily
  3. Alprazolam 0.5 mg three times daily as maintenance therapy
  4. An SSRI such as sertraline combined with cognitive behavioral therapy

Sample question 2

A 42-year-old woman presents with 4 weeks of persistent sadness, anhedonia, fatigue, poor concentration, insomnia, and a 10-pound weight loss. She reports feeling worthless and has passive thoughts of death but denies a specific plan or intent. Her PHQ-9 score is 18 (moderately severe). She has no prior psychiatric history and takes no medications. What is the most appropriate initial treatment plan?

  1. Refer to psychiatry before initiating any treatment
  2. Prescribe alprazolam for anxiety and insomnia and reassess in 1 month
  3. Start fluoxetine 60 mg daily for faster response
  4. Start sertraline 50 mg daily with safety planning and 2-week follow-up

Create a free PulseMD account to answer these, see the explanations, and practice five minutes a day.

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