12 board-style questions on anemia in the PulseMD family medicine question bank — physician-reviewed, written against current guidelines with the reference cited on each question. Two free samples below; the full set with answers, explanations, and spaced review is free to start.
A 48-year-old man of Northern European descent presents with fatigue, joint pain in his hands (particularly the second and third metacarpophalangeal joints), and new-onset diabetes mellitus. Physical examination reveals bronzed skin and mild hepatomegaly. Laboratory studies show ferritin 1,850 ng/mL (normal 12-300), transferrin saturation 68% (normal 20-50%), AST 65 U/L, and ALT 72 U/L. Which of the following is the most appropriate next step in the diagnostic evaluation?
A 50-year-old woman reports an uncomfortable crawling and tingling sensation deep in both legs that occurs primarily in the evening when she is sitting or lying down. The sensation creates an irresistible urge to move her legs, and walking around the room provides immediate relief. She has a history of iron deficiency anemia with ferritin level of 18 ng/mL. What is the most appropriate initial treatment?
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